Tag: cancer

Latest news on selenium

Claus Hancke

January 12, 2010

Intensive research is going on in utilization of selenium against cancer.
The public in Denmark do not hear much of it, but here is a selection of recent news.

The lack of television and newspaper information may give the impression that there is quiet on the antioxidant front concerning disease control. This is not the case. The news shortage is chiefly due to the censorship that has been introduced. Regarding selenium alone, being one of the major antioxidants, there were in 2009 published more than 900 scientific articles. Here we will mention a selection of recent articles about selenium in the fight against cancer.

A famous attempt to demonstrate whether antioxidants protect against cancer were performed in the years 1985-91 in the Chinese Linxian province. Nearly 30.000 participated in the study, which showed a strong decrease in cancer risk among those who received a supplement of selenium (50 micrograms) and Vitamin E and Beta Carotene (respectively 30 and 15 mg). Now it has been determined, what had happened to the participants 10 years later (2001). Even after so long a time, there were relatively more survivors in this group than among those who received other supplements (eg. Vitamin A + zinc, was of no benefit). In particular, the group had reduced incidence of cancer of the stomach, but it was the participants under 55 years of age who experienced the greatest gain – you must avoid lacking vital nutrients already from the youth.

Apparently this result is contradicted by another famous study, the SELECT trial conducted in the U.S. Here it appeared that you could not prevent prostate cancer using selenium, vitamin E or a combination of both. This study was in large scale and the result a huge disappointment.

One of the world’s leading selenium specialists, Margaret Rayman, did point out however, a few months ago what really is obvious: Supplementation with selenium is of no benefit if you already get enough! As a general rule you get enough in the U.S., where you typically get 3-4 times as much selenium in the diet as in Denmark. Sufficient selenium is essential for the body to form enough of the enzymes which we presume protects against cancer. Amongst others Rayman refer to another U.S. cancer trial where you just saw a massive impact in those who received the least amount of selenium, but no effect in those who got the most.

Heavy metals neutralized
One of the veterans in selenium research is Gerhard Schrauzer from San Diego University of California. He has been involved more than 20 years. Now he points out that selenium is able to detoxify numerous toxic metals that somehow during our civilized environment ends up in our bodies. This applies to lead, mercury, copper, cadmium, arsenic, etc. Selenium inactivates these metals by forming insoluble compounds with them. But, says Schrauzer, one must remember that at the same time selenium is used up, so we for that reason are less protected against cancer. In Europe we already get too little selenium, but heavy metals etc. increases the demand.

Taylor and associates have written an article on new advances in selenium research. They write that the renewed interest in selenium is linked to the fact that the anti-cancer effect is now very well documented in animal studies. This is worth noticing.

And precisely on animals a research team from San Diego University have demonstrated that the effect of chemotherapy (cisplatin) against cancer of the colon is reinforced considerably by large supplements of antioxidants (A and vitamin E and selenium) combined with fish oil. The group believes their achievement justifies that research is made with people. The result is very exciting because cancer doctors in this country often discourages in strong terms their patients from combining antioxidants with chemotherapy. The reason for this warning has hitherto been unclear.

Selenium and chemotherapy
Researchers from The Karolinska Hospital in Stockholm state without hesitation that it is well documented that selenium prevents cancer. They describe several experiments which have shown that selenium has strong anti cancer effects – especially against cancer, which no longer responds to chemotherapy. Normal cells will not be harmed by the selenium doses needed for this!

Italian researchers, however, stresses that people can get too much selenium (but living in Denmark you have take approx. two selenium tablets a day in order to get the same amount as a typical American). They argue that high doses may increase the risk of diabetes, an assertion, however, that is controversial.

In the Netherlands, like in China there has been an interest in selenium and cancer of the esophagus. More than 120,000 persons who was 55-69 years old in 1968, delivered at that time, a portion nail clips from their big toes. 16 years later it was found who and how many have got cancer of the esophagus or stomach in the meantime. Then the selenium levels in their nails was measured and compared with the levels in healthy subjects. It was found that the risk of both cancers was significantly higher among those who only had small amounts of selenium in their nails, and hence their body.

A curious study has been conducted in Japan. Here researchers cultivated broccoli-sprouts in a selenium-rich environment, so the sprouts got an extra high content of selenium. In a laboratory study the sprouts was investigated for their impact on prostate cancer tissue. The enriched sprouts inhibited cancer growth clearly better than normal sprouts. Now the Japanese suggests, that men eat that kind of sprouts to prevent cancer of the prostate.

Finally other Japanese mention, that it is well known that selenium can kill cancer cells from humans, but but precisely how this happens is still unclear. They have reached the conclusion that at least part of the effect is due to selenium starts off a cancer cell death process using the same mechanism (apoptosis) as when normal cells must be replaced and die. Such a mechanism is of course necessary, since almost all normal cells divide continuously. There would soon be twice as many, and we would grow indefinitely, if not worn-out cells were put out.

As you can see, the research is really alive. Much of our understanding of selenium is achieved in very recent years. More will undoubtly follow.

By: Niels Hertz, M.D.

References
1. Qiao YL et al. Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. J Natl Cancer Inst. 2009 Apr 1;101(7):507-18. Epub 2009 Mar 24.
2. Lippman SM et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009 Jan 7;301(1):39-51. Epub 2008 Dec 9.
3. Rayman MP. Selenoproteins and human health: insights from epidemiological data.
Biochim Biophys Acta. 2009 Nov;1790(11):1533-40. Epub 2009 Mar 25.
4. Schrauzer GN Selenium and selenium-antagonistic elements in nutritional cancer prevention.
Crit Rev Biotechnol. 2009;29(1):10-7.
5. Taylor D. Recent developments in selenium research. Br J Biomed Sci. 2009;66(2):107-16; quiz 129.
6. Ma H. Bi Efficacy of dietary antioxidants combined with a chemotherapeutic agent on human colon cancer progression in a fluorescent orthotopic mouse model. Anticancer Res. 2009 Jul;29(7):2421-6.
7. Selenius M. Selenium and selenoproteins in the treatment and diagnostics of cancer.
Antioxid Redox Signal. 2009 Sep 21. [Epub ahead of print]
8. Vinceti M. Risk of chronic low-dose selenium overexposure in humans: insights from epidemiology and biochemistry Rev Environ Health. 2009 Jul-Sep;24(3):231-48.
9. Steevens J. Selenium status and the risk of esophageal and gastric cancer subtypes: the Netherlands cohort study. Gastroenterology.. [Epub ahead of print]
10. Abdulah R. Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. BMC Cancer. 2009 Nov 30;9:414.

Vitamin C slows cancer growth

Claus Hancke

August 13. 2008

More than 30 years of experience have shown the anti-cancer effect of vitamin C in both test tubes, animal tests and human trials.

Nevertheless, the Danish Cancer Society (Kræftens Bekæmpelse) does not consider it acceptable to apply yet.

Well-known effect on humans
As early as 1936, a young registrar at the Blegdam Hospital in Copenhagen published in the danish scientific journal “Ugeskrift for Læger” an experiment on two leukemia patients in which the disease improved on treatment with vitamin C (1). The young registrar was later to become the renowned professor of pediatrics, Preben Plum.

Forty years ago, researchers first found that vitamin C selectively kills cancer cells in tumors (2), and already 7 years later, Nobel laureate Linus Pauling and Scottish surgeon Ewan Cameron were able to publish a study in which they found an unprecedented survival time for cancer patients treated with vitamin C (3), and they could reproduce the results a few years later (4).

The Mayo Clinic in the USA quickly put a lid on the debate with a study on cancer patients with very small doses of vitamin C given as tablets, where, as you know, you can not consume very much until you get diarrhea; – the body’s natural “overflow valve”.

In 1982, Japanese researchers were able to reproduce Pauling and Cameron’s unusually long survival for cancer patients on Vitamin C (5).

Since then, numerous both animal and human trials have been published to treat cancer with vitamin C.

The new breakthrough
A few years ago, the National Institutes of Health (NIH) in the United States began to look at the old experiments extra carefully and found it relevant to retest them, and in 2006 they published a large-scale laboratory experiment that showed that when exposing cancer cells to vitamin C in the high doses that can be obtained by intravenous administration, it causes increased cell death in the cancer cells, that is without damaging the normal cells (6).

This prompted the NIH to move on, and last week we heard about their latest publication (7), where they had shown significant tumor size shrinkage in mice with implanted cancerous tumors treated with intravenous vitamin C.

The new skepticism
Now one would think that this news was received with enthusiasm and optimism in an organization like the Danish Cancer Society, whose main goal is probably best described in the name of the association; -but no.

We see in today’s newspaper BT that Anja Olsen from the Danish Cancer Society, who actually researches in diet and lifestyle’s significance for cancer, is absolutely not thrilled.

She tells BT: “It is ethically on the edge to treat with vitamin C. New treatments must be approved according to completely fixed rules, which means, among other things, that research must be carried out based on humans. “Until this is done, we do not know if it works, just as we can not rule out side effects,” she says.

Of course, it is easy for a researcher in the Danish Cancer Society to demand more research. That is what the Danish Cancer Society does. And how easy it is to spend more time on research when you have no illness yourself. But here “the film breaks off”.

The Danish Cancer Society (DCS) must wake up
For researchers far from patients and for administrators behind closed doors, of course, it is difficult to imagine; but as any general practitioner knows, the time factor for a cancer patient is of completely different dimensions than for the healthy.

The patient who has terminal supplements because “further treatment is hopeless” does not have a time frame of several years before it turns out whether a treatment works or not. He can not say “let’s wait and see”, because then he will never see.

He is looking for a way to prolong life and gain a little extra time. Shouldn’t he have that opportunity? And is it not better that he chooses a treatment which rests on evidence than anything else?

In addition, we have a treatment that has been free of side effects for 10-15 years of use, and a treatment that has numerous both animal experiments and human experiments as evidence.

Wake up DCS and stop moralizing. It can not be justified.

Denmark has a top position in cancer incidence and a bottom position in cancer treatment.

More clinics
A side-effect-free cancer treatment that selectively hits cancer cells without damaging normal cells at the same time is the ideal cancer treatment.

Once it seeps into the public health service and the Danish Cancer Society how good a palliative and life-prolonging treatment Vitamin C can be, then we must hope that large outpatient clinics will be established so that this treatment in the future can be offered for free to cancer patients in Denmark.

The Vitality Council.

References:
1. Plum P. Thomsen S. (1936) Remission under forløbet af akut aleukæmisk leukæmi iagttaget i to tilfælde under behandling med ascorbinsyre. Ugeskr. Læger (98):1062-67.
2. Benade L. Howard T. Burk D. (1969) Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-1, 2, 4, -triazole, Oncology, 23, 33–43.
3. Cameron E. Pauling L. (1976) Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA, 73, 3685–3689 .
4. Cameron E. Pauling L. (1978) Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer, Proc Natl Acad Sci USA, 75, 4538–4542 .
5. Murata A. Morishige F. Yamaguchi H. (1982) Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate, International Journal for Vitamin and Nutrition Research, Supplement, 23, 101-113.
6. Chen et al. Proceedings of the National Academy of Sciences 20.Sep.2005;102:13604-9
7. NIH News (2008) Vitamin C Injections Slow Tumor Growth in Mice, Embargoed for Release, Monday, August 4,

Vitamin C inhibits cancer. But How?

Claus Hancke

September 18, 2007

New research sparks new theories about how vitamin C inhibits cancerous growth.

A great deal of research indicates that vitamin C has a considerable inhibitory effect on the growth of cancer cells.

The biochemical effect of high-dose treatment with vitamin C is reasonably understood; vitamin C acts as a pro-oxidant on cancer cells at such doses. This causes increased free radical strain on the cancer cells and thereby acts as a poison to the cancer.

In moderate doses, the kind of doses which we can get through our diets, vitamin C is an antioxidant. But even at these doses, vitamin C has shown an inhibitory effect on the growth of cancer cells.

It was therefore believed that vitamin C blocks the free radicals which cause the cancer forming mutations in the cells, and that the reason for its protective effects is that it protects the cells’ DNA.

This is presumably not the whole truth.

Many years ago a famous professor by the name of Warburg was among the first to maintain that cancer cells grow in oxygen poor tissue. Today this is common knowledge, but there lacks knowledge on how this occurs. Ten years ago Gregg Semenza of John Hopkins University found that cancer cells are dependent on a protein called HIF-1 (hypoxia induced factor), which helps the cells by compensating for lacking oxygen in the surrounding tissue and thus allows cancer cells to convert sugar to energy without oxygen. HIF-1 also catalyses the creation of new blood vessels so that hungry cancer cells can get fresh supplies of nutrients and oxygen. If a cancer grows aggressively, it quickly uses up its oxygen supply and becomes entirely dependent on HIF-1. The HIF-1 protein is dependent on the presence of free radicals, which are also necessary for many other processes in the body. A powerful antioxidant like vitamin C eliminates the surplus of free radicals, which causes HIF-1 to become ineffective and thus inhibits cancer growth.

This new theory is based on a study done by a research group at the centre of oncology at John Hopkins University in conjunction with Dean Felsher of Stanford.

They set out to study antioxidants’ roles in cancer growth and found, to their great surprise, that antioxidants destabilise the protein on which cancer cells are dependent. As professor Chi Dang from John Hopkins University wisely stated, “By uncovering the mechanism behind anti-oxidants, we are now better suited to maximize their therapeutic use.”

By: Claus Hancke, MD

Reference

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo. Cancer Cell, Volume 12, Issue 3, 11 September 2007, Pages 230-238Ping Gao, Huafeng Zhang, Ramani Dinavahi, Feng Li, Yan Xiang, Venu Raman, Zaver M. Bhujwalla, Dean W. Felsher, Linzhao Cheng, Jonathan Pevsner et al.

www.cancercell.org

Vitamin D inhibits cancer

Niels Hertz

June 26, 2007

An overlooked but very sensational study suggests that vitamin D could inhibit almost 80% of all cancer cases. We just need much more than we normally get (1).

One out of every three people in Britain die of cancer and a world without this feared disease seems utopian. But if an American study is correct, we can approach this unattainable goal with a historic leap forward. We just need more, much more, vitamin D, and maybe also more calcium. According to the study, a combination of calcium and vitamin D can reduce the risk of cancer by about 60%. Additionally, it seems that if cancer is avoided during the first year of taking supplements, then the risk of cancer the following year is reduced by nearly 80%! It is hard to expect more.

It is strange that such sensational news has received almost no official consideration. Especially because it comes from a highly trustworthy double blind, randomised trail published by highly respected researchers.

The participants in the study were 1,180 women with an average age of 67. They were from Nebraska, which is just as far south as southern Italy and receives a lot of sun. Not surprisingly the women had on average good blood levels of vitamin D before the study.

In the study 446 of the women received an advantageous daily supplement of as much as 1,100 units (27.5 micrograms) vitamin D. This is at least five times more than the contents of a normal vitamin pill and about three times the recommended dosage for people over age 60. They also received 1.5 gr. calcium (as carbonate or citrate), which is about the amount of calcium in a litre of milk.

Another 445 women received only calcium and 288 received placebo. Neither the women nor the researchers knew who got what. The study lasted for four years while it was noted who and how many got cancer.

We now have the results. The group which received the vitamin D and calcium was subject to many fewer cases of cancer than the group which received placebo. The difference was not coincidence! It was statistically extremely solid. The biggest difference (77% lower risk) was shown during the last three years of the study. The researchers surmised that this was because some of those who got cancer in the beginning of the study already had undetected cancer before the study started.

It could be true
The women who just received calcium also had a lower risk of cancer (40%). This finding was not completely certain statistically. The cancer risk for these women did not, as in them who received both vitamin D and calcium, become more reduced after the first year. It is therefore uncertain if this effect is actual or just the result of coincidence.

On the other hand, at least two further arguments indicate that vitamin D actually works. The first is that the women who had the poorest vitamin D status before the study, were those helped the most, their risk was the most reduced. The vitamin D status of the participants during the study also played a role, the lower the status, despite the supplements, the larger the cancer risk. The second argument that vitamin D has this effect is that the risk was directly link to the amount of vitamin D used.

Can it really be true that something as cheap as vitamin D can be so beneficial? We know that the vitamin regulates at least 200 genes, many of which control the cells’ growth and degree of specialisation. Animal studies have shown that vitamin D deficiency promotes cancer growth. For more than 60 years it has been known that cancer is less common in countries where the sun is high in the heavens leading to the production of more vitamin D in the skin. It has also be proven time and time again that low vitamin D status and high cancer risk in people go hand in hand (2,3).

The only thing that has been missing is a proper study with sufficient supplements so that cause and effect could be analysed. We now have just that study!

The women in Nebraska had a typical vitamin D status (25-hydroxy-vitamin-D3 in the serum) of 71 nanomolsl/L before the study. This is a very acceptable value. But the supplement increased this value to an average of 96. This is normally regarded as too high.

Vitamin D status is measured with a blood test! It is most important during the winter, when it is the lowest. According to the Nebraska study, this level should be no less than 100.

By: Vitality Council

References: 

1) Lappe J M et al. Vitamin D and calcium supplementation reduces cancer risk: Results of a randomized trial. Am J Clin Nutr 2007;85:1586-91.

2) Feskanich D et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 2004;13:1501-8

3) Ahonen M H et al. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 2000;11:847-52

www.ajcn.org
cebp.aacrjournals.org
www.springerlink.com/content/0957-5243

Vitamin D Could Prevent Every Third Cancer-related Death

Claus Hancke

April 21, 2006

Several of the World’s leading vitamin researchers advocate a much higher vitamin D-intake. They believe that up to every third death from cancer may be prevented.

“I challenge anyone to find a field or a nutritional substance or any other factor with as effective cancer-fighting properties as vitamin D.”

So said Edward Giovanucci, professor at Harvard University, last year in a speech to the American Society for Cancer Research.

More and more agree with Giovanucci, amongst them, several professors from well-renowned universities. A few months ago Cedric Garland, an absolute pioneer in the field, stated that it has been proved that the risk of cancer can be lowered dramatically with vitamin D. These are big words. Garland is a professor at the University of California in San Diego.

Giovanucci has together with six others, of these, no less than three are professors from Harvard, confirmed the claim further. In a quite laborious study they have confirmed the close connection between a vitamin D deficiency and cancer.

Since World War II it has been known that especially cancer in the alimentary canal is seen relatively seldom in southern countries. Since sunlight is the most important source of vitamin D, it has earlier been guessed that it was vitamin D and not the sun, which offers protection. In numerous studies the incidence of cancer has been found to be highest where sunlight is weakest, and where the content of vitamin D in the blood is lowest. We are children of the sun. At the same time laboratory research in recent years has shown that this vitamin inhibits the growth of abnormal cells, counteracts the spread of cancer and prevents the formation of blood vessels in tumorous masses.

Giovanucci now finds further proof of the connection. Earlier in humans there has only been found an indirect connection between vitamin D and cancer. There has been a lack of data from whole groups of the population, that have had their blood content of vitamin D measured, and have then been followed for a number of years. But Giovanucci has found something to substitute this data.

Mega doses of Vitamin D
They took 1095 men from the big population study “Health Professionals Follow-Up Study”. These 1095 men had had their vitamin D-status measured (this means the content of vitamin D in the blood). In addition, a lot of things were known about their personal habits etc. Would it be possible to go backwards and calculate their vitamin D-status from their personal habits? Yes! An estimation of the approximate vitamin D blood content could be made, when the individual’s skin colour (eg. race), body mass, height, place of residence (southern/northern in the USA), the amount of physical activity, time of year and the content of vitamin D in the test subject’s diet and possibly supplements was known.

In this manner the group worked out a point-system for the direct calculation of vitamin D status. What especially contributed to a low status was a northern place of residence, dark skin colour, overweight and lack of exercise. The calculations proved correct for the 1095 test subjects. But would they be correct for other people? They were checked for another group of men with known vitamin D status. They were consistent!

Every single subject, of the 47,800 men in Health Professionals Follow-Up Study now had their vitamin D status calculated. In the course of approximately four years, about one in ten got cancer. About half that died from it.

To find the significance of vitamin D, they chose to compare dead men whose plasma values for vitamin D (25(OH)D3) deviated by 25 nmol/L (nanomol/liter). It was found that the risk of dying from cancer was no less than 29 percent lower in men with a high vitamin D status. Concerning cancer of the alimentary canal – it was 45 percent lower for men, who were otherwise identical with regards to age, weight and level of physical activity.

If these results are correct, every third death from cancer may be prevented in the course of a few years. Also in the UK. This is nothing but a sensation. But if one wishes to increase the plasma level of vitamin D by 25 nmol/L, one must receive a supplement of no less than 1,500 units of vitamin D during the winter. This is achieved if a supplement of four vitamin D tablets of 10 mcg (micrograms) is taken daily from August until April.

1,500 units will probably shock many. Is it not toxic? No, it is quite certain that there is no risk, even with a permanent supplement of 2,000 units daily. For comparison, the skin produces 20,000 units during half an hour in the sun in the summer.

Garland, who was mentioned above, recommends 1,000 units (25 micrograms) a day. Others say 2,000. Giovanucci and his colleagues from Harvard strongly recommend 1,500.

Under any circumstances: If you want the full advantage of vitamin D, it seems that the need is far greater than what we have gotten used to believe. Maybe it is close to what stone-age people received naturally from their diet.

By: Vitality Council

References
1. Giovanucci E et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 2006;98:451-9
2. Garland CF et al. The Role of Vitamin D in Cancer Prevention. Am J Public Health. 2006;96(2):9-18. 2005 Dec 27; [Epub ahead of print]

jncicancerspectrum.oxfordjournals.org
www.ajph.org
www.iom.dk

Vitamin D as a Universal Remedy

Claus Hancke

September 13, 2005

Vitamin D, which most people lack in the winter and many lack in the summer, has an increasing number of roles to play. A deficiency in Vitamin D increases the risk of multiple sclerosis, several types of cancer, skin diseases, and even increased blood pressure.

Vitamin D plays an important role in the public consciousness, but even a bigger role in the minds of those who develop new medicine. Substances which are related to vitamin D are central to the treatment of many serious diseases. This is shown by a comprehensive and very well documented summary from the American pharmaceutical giant Eli-Lily.

In this summary the status and possibility of vitamin D treatment for (among others) prostate cancer, enlarged prostate, breast cancer, rheumatoid arthritis, psoriasis, leukaemia, multiple sclerosis, type I diabetes, skin cancer, hypertension, and of course osteoporosis is examined.

Here are some examples:

Multiple sclerosis (MS) is a so called autoimmune disease, which means that it is a disease where the body’s immune system turns against parts of the body itself, in this case nerve tissue. In animal models of this disease it is possible to avoid outbreaks with the help of calcitriol. Calcitriol is the active version of the vitamin and is created as needed by the body so long as the vitamin D deposits are sufficient. MS is most common in temperate countries, where the sun in relatively low in the sky and vitamin D deficiency is common.

Rheumatoid arthritis is also an autoimmune disease, but with this disease the joints are attacked by the immune system. People with small vitamin D depots more often suffer from rheumatoid arthritis and the risk is higher in temperate countries than in subtropical climes. In animals it is possible to avoid worsening of symptoms if calcitriol is given early enough.

Psoriasis is already treated with salves which contain the vitamin D containing substance calcipotirol (Daivonex), which helps at least 70% of sufferers. Sunlight also helps. Like vitamin D, calcipotirol has the ability to help cells become mature and specialized without growing uncontrolled.

Death rates from prostate cancer are lowest in sunny countries, and the risk of getting this disease is highest in men who have small vitamin D deposits. In a study prostate cancer growth was inhibited in six out of seven patients with the help of calcitriol tablets (0.5-2.5 microgram per day). This is also explained by the vitamin’s effects on the cells. Because normal prostate cell growth is also slowed, researchers also see a possibility of using such treatment for enlarged prostate.

Breast cancer and colon cancer are more common in people who do no get much sun. Both the growth and the spread of breast cancer are reduced by calcitriol in animal studies. Regarding colon cancer, increased growth has been seen in animals that were artificially given vitamin D deficiency. This cancer inhibiting property is predicted to play an important role in future treatment.

Finally, hypertension should be considered. Lack of sunlight and vitamin D in the blood are believed to contribute to high blood pressure. High blood pressure is quickly caused (in mice) by avoiding vitamin D.

All of the above illnesses have the common factor that they can be provoked by lack of sunlight, the most important source of vitamin D. They are also counteracted by vitamin D and vitamin D like substances.

One could wish that it would be possible to treat and prevent these illnesses with the active form of vitamin D, calcitriol. But this is a risky method which can lead to increase calcium levels in the blood and kidney stones. Therefore we must be content with getting vitamin D the natural way, which is to say from sunlight or by eating fatty fish, and then let the organism create calcitriol as needed.

Unfortunately at our latitudes the fours summer months from May to August are the only months where there is enough sun that we create vitamin D in the skin. Those who do not come out in the sun or are covered in clothing, do not create near enough. This makes it necessary to take vitamin D in pill form.

The task is to get enough vitamin D. This is not possible during the dark months without vitamin supplements or eating a lot of fatty fish. Deficiency creates a larger problem than many are aware.

By: Vitality Council

Reference:
Nagpal S et al. Noncalcemic actions of vitamin D receptor ligands. Endocrine Reviews 2005;26:662-87.

edrv.endojournals.org
www.iom.dk

Green Diet And Antioxidants Act Against Prostate Cancer

Claus Hancke

August 16, 2005

A radically changed lifestyle together with antioxidant supplementation seems to stop the growth of early prostate cancer, while the blood becomes eight times more capable of fighting cancer cells.

Some studies with humans and numerous animal trials and population surveys have indicated that antioxidants counteract cancer. Nevertheless, only a few researchers have examined whether they help against cancer in humans when the disease is a reality. An American trial now shows that this may be the case, at least by cancer in the prostate.

The trial, which has just been published, included 93 men with early-stage prostate cancer. They were selected because they had refused to accept usual cancer treatment.

44 of them were instructed to follow a fairly strict diet where only 10% of calories were allowed to come from fat. They had to have a pure plant diet and avoid dairy products, but in return received a protein supplement in the form of a soy drink. In addition, they had to exercise equivalent to half an hour of brisk walking a day and had to perform various yoga exercises and meditate for another hour. Of course they weren’t allowed to smoke!

You’d think most people would quickly give up such a strict lifestyle. But the vast majority persist, perhaps because they are doing well. The leader of the trial, Dean Ornish, has described that when he let a group of men with bad hearts follow this recipe, their atherosclerosis in the coronary arteries of the heart decreased – mind you, not just in the first year, but quietly in a continuing process that all in all lasted at least five years.

In the current trial, however, Ornish supplemented with nutritional supplements:

  • Vitamin E 400 units/day.
  • Vitamin C: 2 grams/day.
  • Selenium: 200 micrograms/day.
  • Fish oil: 3 grams/day.

Better after a year
All had the so-called PSA value measured, first at the start of the experiment, and again after one year. PSA (Prostate-Specific Antigen) is an approximate expression of the spread of the cancer. That was the main purpose of the trial to measure what happened to PSA.

What happened was that when a year had passed, the PSA value had fallen by an average of 4% in the 44 in active treatment, while that in the control group – which was closely followed by their own doctor – had increased by 6%.

That in itself was an exciting result. But in addition, six men from the placebo group became so ill that they had to withdraw from the trial and undergo traditional treatment. If the six men from the control group had not dropped out – because they became very ill – the difference would have been even greater.

No actively treated patients left the trial
As a supplement to the PSA measurements, one more experiment was performed. They took serum from all participants and examined how it affected the growth of prostate cancer cells in laboratory experiments. After a year, a huge difference had emerged: the treated men’s serum inhibited the growth of cancer cells eight times as much as the control group’s!

These results are statistically very confident. One must therefore expect that there is an effect, but what causes it? Was it the predominantly green diet, soy, exercise – or perhaps yoga and meditation? Or was it the antioxidants?

One can only guess. Dean Ornish believes that overall lifestyle changes made the difference. But the assumption that antioxidants help against cancer is of course supported. In any case, the experiment is highly thought-provoking.

By: Vitality Council

References:
Ornish D et al. Intensive lifestyle changes may affect the progression of prostate cancer. The Journal of Urology 2005;174:1065-70.
Ornish D et al. Intensive lifestyle changes for reversal of coronary heart disease. JAMA 1998;280:2001-7.

The Role of Antioxidants May Have To Be Reassessed

Claus Hancke

February 27, 2004

British scientists have discovered that it is enzymes and not antioxidants that are the active factor, when white blood cells attack bacteria.

Free radicals are aggressive molecules that are capable of destroying the structure of other molecules. For example, the body uses free radicals to cut large molecules into pieces and build complex protein structures. So far so good.

But an abundance of free radicals has been shown to be able to damage the body due to the deterioration (oxidation) of certain molecules, such as LDL cholesterol, which then becomes dangerous because it causes arteriosclerosis in its rancid (oxidized) form.

In order to slow down this harmful oxidation, we form the so-called antioxidants. These are also found in our diet and in several dietary supplements. For example, vitamins C and E are such antioxidants.

However, a British research team has investigated the reactions that occur in the white blood cells when these attack bacteria. And they found that free radicals did not play a role, but rather that it was enzymes that the white blood cells use to attack and destroy bacteria.

Until now, it has been believed that the white blood cells used free radicals, and therefore people have been reluctant to use excessive doses of antioxidants, because it was believed that this would neutralize the white blood cells’ free radicals, so that they could not fight bacteria.

The new theory may explain why even large doses of antioxidants have not shown an inhibitory effect on the antibacterial effect of the white blood cells.

A large number of questions now remain, including the scientifically documented inhibitory effect on the occurrence of cancer and cardiovascular diseases.

There is no doubt that there will be renewed debate about this every time we see new research in this very exciting area. – Also because opinions are divided. But one thing is theory, another is practice.

We must remember that the knowledge of medical science today is wrong. All the history of science has taught us that. In 100 years, our current theories will be replaced by new ones, and people will smile at the official knowledge of today.

We must therefore be careful, and above all let ourselves be guided by the large clinical studies. The theories must then try to explain these results.

By: Vitality Council

Reference:
Nature, vol 427;6977:853.

www.nature.com/index.html
www.iom.dk

Fruit and vegetable antioxidants could significantly reduce cancer risk

Admin

June 25,  2003

Eating sufficient fruit and vegetables to maintain antioxidant vitamin and mineral levels could reduce the risk of cancer and mortality in men, report researchers from the French health and medical institute Inserm.

An eight-year study found a 30 per cent reduction in cancers and 37 per cent reduction in mortality among men who received a daily antioxidant supplement compared to placebo. The researchers claim that the study, called SU.VI.MAX, is the first randomised trial to show that an adequate intake of vitamins and minerals from fruit and vegetables can reduce the risk of cancer.

The double-blind, placebo-controlled study tested the impact of a daily dose of antioxidants on 13000 healthy subjects. The dose included 6mg of beta-carotene, 120mg of vitamin C, 30mg of vitamin E, 100ug of selenium and 20mg of zinc. The 7886 women, aged 35 to 60 years old, and 5141 men, from 45 to 60 years old, were divided into two groups and followed up over an average of 7.5 years.

There was no difference between the two groups concerning heart disease, supporting other studies testing the effects of antioxidants on cardiovascular health, but cancer risk was reduced by 31 per cent among men. This included most cancers, especially digestive, respiratory and skin cancers.

The absence of such effects in women was not due to the different cancers they developed but rather their better state of health at baseline, explained the Inserm researchers.

Again, while risk of death was 37 per cent lower among men receiving the supplements, the same effect was not seen in women. The researchers also found a higher risk of cancer and heart disease among men with the lowest levels of beta-carotene. The lower the level of the nutrient, the higher the risk of disease. The team stressed however that the findings should support a nutritious diet with regular consumption of fruit and vegetables rather than supplements.

Use of antioxidant supplements was necessary to be able to compare to placebo, but they claim that this effect applies equally to nutrients found readily in plant foods. The results back nutrition advice to consume at least five portions of fruit and vegetables daily rather than relying on supplements, claim the researchers.

They add that the observed effect is likely weaker than would be seen from fruit and vegetables, which have additional nutrients not included in the supplement used in the study. Further, they pointed to fears that people taking supplements may eat less fruit and vegetables, calorie sources which often lead to reduction in consumption of fatty and sugary products.

Source: NutraIngredients.com