Tag: cytokine storm

Basic prevention

Claus Hancke

July 28, 2021

In March 2020, politicians shut the world down on pandemic orders from the WHO.
It did not take many seconds from the shutdown before the talk went on that vaccines had to be developed that could free us from this covid-19 disease.
It was established from the outset that the disease could neither be prevented nor treated. There was only isolation until the saving vaccine came.
It was “The one-legged stool”, as mentioned in our newsletter feb. 21, 2021.

If anything was fake news, it was this.
But for inexplicable reasons it became the standing narrative, which was so sacred that one was shamed and censored if one doubted this worldview.

All over the world, doctors were prevented from rescuing their patients by early prevention and treatment of covid-19.
It sounds crazy that one has censored and prevented harmless methods of prevention and treatment before it goes so wrong that the patient has to be hospitalized.
Do the authorities really want people to get so ill that they have to be hospitalized?
Some of these harmless methods are even well documented, yet it is branded as “fake news” when it is publicly mentioned and the doctors in question are quarantined on Facebook and YouTube.

However, measures such as shutdowns and face masks are blindly accepted, even though there is very little documentation of the effect.
Health authorities as well as politicians from all over the world have loudly and sacredly emphasized that we must follow the science, and the world’s all-round experts have been shown on TV to give the authorities’ actions a tinge of science.

But when it comes to shutdowns, mink killings, face masks, PCR testing and the so-called vaccine, which is in fact a gene therapy, these highly praised scientific principles have failed.
We have even come so far that the population must be humiliated with testing or subjected to experimental gene therapy in order to preserve its civil rights.
Every thinking person must ask oneself: Tell me, what is going on?

If you want to try to get an overview of this madness, it is recommended to spend time watching: https://www.markmallett.com/blog/following-the-science/, which is a serious TV review of the conflict between science and the active deception of the authorities.

The Vitality Council is fortunately uncensored, and in the newsletter May 2020, there was a comprehensive overview of the supplements with which one could prevent a serious Covid-19 course.
The main thing is that the immune system must not lack these basic nutrients. On the other hand, a well-functioning immune system has the great advantage that it can quickly adapt to a new mutation of the virus and adjust its counter-attack to it.
A vaccine is specially designed for a specific type of virus, and must be reconstructed and adjusted if a new VOC (“virus of concern”, ie mutations that are viewed with concern) varies so much from the previous one that the vaccine does not work.
We see this at this time at home and abroad, where fully vaccinated people are admitted with severe covid-19.
This would not happen if the entire population had a well-functioning immune system that can quickly adjust the target to the new variant.
Then you only need to vaccinate the 2% who are in the absolute risk group.

But one thing is to prevent serious flu or Covid-19. Something else is the prevention of the major killer diseases like cancer and cardiovascular disease.
These disorders have been underdiagnosed during the Covid-19 pandemic, which must necessarily become a problem for the healthcare system in the coming years.
But then it is fortunate that many of the supplements that the Vitality Council recommended 1½ years ago also reduce the risk of these diseases.
This is not really so strange, for many diseases start with the process called inflammation. And it can be prevented to a great extent.
Regarding Covid-19, it starts with the immunological reaction to viral infection, the excessive reaction, the cytokine storm and then the whole inflammatory process.
In cardiovascular disease it starts with inflammation of the vessel wall and oxidation of LDL cholesterol, and in cancer it starts with inflammation of the cells in an oxygen-poor area, which then changes the metabolism in the mitochondria from aerobic and efficient energy production to anaerobic sugar fermentation and low energy production.
Therefore, if you focus on inhibiting the inflammatory processes that should not be in the body, then you are well on your way to preventing the large, life-threatening diseases, and at the same time you get to inhibit the development of viral diseases so that they do not develop in a fatal direction.
Therefore, if I have to come up with an all-round recommendation as a basis, then it will be:

  • A multivitamin-mineral product without iron
  • Plus extra Selenium, so the daily dose comes up to 150 µg
  • Plus extra vitamin D, so the daily dose is up to 100 µg (this is only the maintenance dose if you are not in deficit. Otherwise you need more.)
  • Plus extra vitamin C, so the daily dose comes up to 2,000 mg
  • Plus extra Magnesium, so the daily dose comes up to 500 mg
  • Fish oil (but not necessary if you eat fatty fish every day)
  • Lactic acid bacteria

This basic supplement can ensure that you do not run a deficit for the body’s performance of tits basic functions, including the processes of the immune system.

If, on top of this, you are exposed to infection, which we have all been at intervals in the last 1½ year, then you can for a period supplement with:

  • Vitamin A: 1 mg
  • Vitamin B6: 5 mg
  • Vitamin C: 3,000 mg
  • Vitamin D3: 100 µg
  • Selenium: 100 µg
  • Zinc: 30 mg.
  • Echinacea 20 drops 2 x dgl.

This ensures that the immune system is well-supplied, despite increasing consumption, and then inhibits the cytokine storm, which can be life-threatening for the elderly and weak.

And the very basics of a good immune system are of course:

  • A healthy diet
  • Daily exercise
  • 7-8 hours of sleep
  • Freedom from smoke
  • Moderation
  • A positive outlook on life

Take care of yourself and others.

Claus Hancke MD
Specialist in general medicine

Don’t forget selenium

Claus Hancke

March 8, 2021

With the headline, we are entering the vital minerals, and selenium is one of the most important, because it is the gateway to 25 different selenoproteins, which control a wide range of processes in the body.

Selenium is a substance that we prefer not to lack, and numerous studies have over the years confirmed that selenium deficiency can lead to, among other things. heart failure, cancer, metabolic disorders, arthritis, infertility, atherosclerosis, increased inflammation, and a variety of immunological failures that are particularly relevant in this corona age.

Did you know, for example, that a vaccine will not work as intended if the vaccinated person lacks selenium and vitamin D. These two nutrients are necessary to activate the T cells, which must be able to recognize the infection the next time you encounter it (1,2,3). And they are also needed to moderate any vaccine-triggered cytokine storm.

There are thousands of articles cementing heavy research into selenium, and most recently, two months ago, an interesting study of selenium deficiency related to cardiovascular disease and inflammatory conditions was published (4). Since cardiovascular disease is also initiated by inflammation, it is natural to examine this collectively.

Previous studies have also shown that low selenium in the blood was the cause of increased inflammation, increased risk of cardiovascular disease and premature death (5,6).

Selenium dampens cytokine storms

The study included 858 healthy elderly and 606 cardiovascular patients of the same age.
The researchers examined the degree of inflammation by measuring the ratio of white blood cells (neutrophil / lymphocyte ratio), CRP and a wide range of cytokines, interleukins and chemokines.

They found a clear link between the lack of selenium and the incidence of cardiovascular disease as well as, not surprisingly, increased chronic, inflammatory load on the body, especially in the cardiovascular disease.

Selenium deficiency was associated with elevated values of circulating inflammation markers such as cytokines, interleukins and chemokines that are precisely characteristic of the scourge of our time, namely the risk of a cytokine storm at Covid-19.

Selenium is included as a moderator on an equal term with vitamin D, so that the formation and control of cytokines is formed and controlled, but to avoid the violent production called a cytokine storm, which triggers the damage that makes Covid-19 dangerous for individuals, weak people.

The researchers concluded that people with plasma selenium below 60 µg / l had almost twice the risk of cardiovascular disease compared to those who had a normal selenium content in the blood.

The result was convincing and statistically significant and corresponds very well to previous studies showing that the selenium-dependent glutathione peroxidase achieves its maximum activity in the blood when the concentration of selenium in plasma is between 70 and 90 µg / l (7).

In previous newsletters from May 2020, there are several references related to infections updated by Covid-19, and back in 2005 we wrote newsletters about cancer risk due to selenium deficiency. So selenium has been on the light board for many years, i.a. because there are so few who are aware that it is something we must not lack.

Daily intake (in Europe) should be around 100µg, and naturally it is found in fish, meat and certain nuts.
So remember selenium every day.

Take care of yourself and others.

Claus Hancke MD
Specialist in general medicine

References

  1. Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study. Piroth L et al, Dec.2020, Lancet. https://www.sciencedirect.com/science/article/pii/S2213260020305270
  2. Geisler C, Ødum N et al. 2010, Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nature Immunology 2010;11:344-349.
    https://www.nature.com/articles/ni.1851
  3. https://www.webapoteket.dk/saar-og-sygepleje/selvtest/quicktest-d-vitamin-p-222465
  4. https://www.cerascreen.dk/products/test-for-d-vitamin
  5. Alberto Boretti, Bimal Krishna Banik (2020) Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome PharmaNutrition. 2020 Jun;12:100190.  Published online 2020 Apr 21. https://www.sciencedirect.com/science/article/abs/pii/S2213434420300153
  6. Caly L et al, 2020, Antiviral Research, 178, june 2020, 104787.
    https://www.sciencedirect.com/science/article/pii/S0166354220302011?via%3Dihub
  7. https://clinicaltrials.gov/ct2/show/NCT04747574

Be prepared for the next Corona epidemic

Claus Hancke

The population is not

May 29, 2020

The Corona is spreading more slowly now, and, here in Denmark, Covid-19 is gradually infecting fewer and fewer people and we are more aware of protecting ourselves against it.

There have been good effects from keeping our distance and from maintaining good hygiene in which we have all been well instructed.

Much to the surprise of the Danish Serum Institute, less than 2% of the Danish population has had the disease, and only a few of these individuals may have obtained immunity to SARS-CoV-2, which the virus is called.
This means that more than 98% have not been infected and are completely without immunity. So forget about herd immunity.

The Danish population is just as vulnerable it was were in March when it all started.

Let’s try to summarize what we know and what we can do about it.

What do we know now?
SARS-CoV-2, which is the virus responsible for the current Covid-19 pandemic, is characterized in that it – like the influenza virus – triggers a reaction with the release of a number of signaling molecules such as interleukins, interferons, and lymphokines.

When this release is powerful, it is called a “cytokine storm”, and with Covid-19, it is so powerful that immune cells begin to damage the tissues where the process is taking place, and, in this case, it is primarily the lung tissue that is damaged.

During the cytokine storm, a violent inflammatory response and increased release of free oxygen radicals are created, which further damages the lung tissue due to the subsequent inflammatory microcoagulation seen in the pulmonary vessels. Adding too much oxygen at this stage will only aggravate the situation, which several anesthesiologists have experienced when Covid-19 patients’ conditions worsen when they are put on a respirator.

What can we do about it
Thus, it is primarily about attenuating the fatal cytokine storm.
Here vitamin D, magnesium, selenium, and vitamin C are particularly important as they specifically inhibit this cytokine storm and the subsequent inflammatory microcoagulation in the pulmonary vessels.
If the level of these essential substances in the body is high enough then you will have a subdued cytokine storm and thus attenuated symptoms, as seen during influenza infection. Fresh extract of Coneflower (Echinacea) has also been documented in several scientific studies to effectively inhibit this cytokine storm.

It should be obvious to protect ourselves by promoting such harmless and inexpensive remedies, but unfortunately in the medical and pharmaceutical world, one tends to stare blindly at the most expensive solutions.
Medical professionals were first intrigued by the antiviral drug Remdesivir, which could shorten the disease period of Covid-19 from 15 to 11 days. This fascination has now been replaced by a new one, another drug, an experimental cancer drug, Bemcentinib that may prevent viruses from entering the cells. A phase II trial is underway for 120 people, and we hope we will be able to get the result in a few months.

Well, it is excellent that medical professionals try to find a medicine that can help in this situation, but is it absolutely necessary to find a new, expensive medicine with side effects, when there are other far cheaper options without side effects?

The long awaited vaccine
While all this is going on, the pharmaceutical industry is working full speed on a vaccine. A vaccine against an RNA virus is very difficult to make, and using a vaccine is especially problematic because viruses constantly mutate and thereby often change the immune response.

No vaccine has ever been safety-tested, in the same way that medicine is tested, and this is a bit problematic because in recent years, the industry has started to add substances whose purpose is to stimulate the immune system for effective antibody formation. And stimulating antibody formation is good enough, too, but the safety of these substances has never been investigated. In Denmark, the use of mercury (thimerosal or thiomersal) in childhood vaccines was stopped from 1992 and in influenza vaccines from 2004, with the exception of the vaccine in 2009, which was an embarrassing exception. The toxic mercury should never be used again for human use – neither in the teeth, for that matter.

But in recent years aluminum has been added in the form of nanoparticles as well as squalene emulsions. These adjuvants have not been safety tested. It has just been noted (WHO has noted) that the number of side effects is not greater than is usually seen with vaccination. Aluminum is a neurotoxin, but it has been used in vaccines in the form of various aluminum salts since 1930, so in that form it probably isn’t particularly harmful. The problem is that nanoparticles are now being used that cannot be stopped by a cell membrane. They can penetrate all tissues.
It cannot be ruled out that it is safe to use these additives. It’s just never been investigated.

It should be a simple task to make a study with each of these ingredients against a real placebo such as brine.
We have many excellent vaccines, so let’s not be vaccine deniers. Let’s welcome a SARS-CoV-2 vaccine when it arrives, and then just hope it is properly safety tested. Of course, this hope becomes a requirement if we are to be mandatory vaccinated.

Of course, the Coronavirus will return
When and how bad we do not know, but it will come.
As mentioned in the Vitamin C newsletter, one of Europe’s experts in Covid-19, Professor Christian Drosten from the University of Berlin, has stated that the second wave could be tougher than the current one.
And since more than 98% of the Danish population is without immunity against it, we should not sit with our hands in our laps and wait for a vaccine.

We need to be proactive.
We need to make sure that we have enough of the nutrients that can reduce the risk of our getting sick, and especially the nutrients that can dampen the cytokine storms, so that we get a mild course of illness if we get sick anyway.

Especially old people and people who eat only very little, who may also be weakened by chronic disease, will do well by supplementing the diet in order to be well equipped with an optimally functioning immune system as the next virus threat approaches.

An appropriate daily dose for a normal-weight adult will typically be:

  • Vitamin A: 1-2 mg
  • Vitamin B6: 4-5 mg
  • Vitamin C: 2-3,000 mg
  • Vitamin D3: 75-100 µg
  • Selenium: 100-200 µg
  • Zinc: 20-30 mg
  • Magnesium: 200-300 mg

Note: The low dose is for those weighing less than 70 kg (155 pounds / 11 stones).

If you start now, you will be prepared in the fall. This is an obvious strategy for the country’s nursing homes.

This is the fifth and final Covid-19 newsletter.

Unfortunately, the five newsletters are necessary as this knowledge and scientific back-up are neglected in the public counseling of the population.

Take care of yourself and others,

Claus Hancke, MD,
Specialist in general medicine

Refs:

  • McGonagle D et al. (2020) Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia. Lancet May 7, 2020:1-9
  • Zhang Y, Leung D, Richers B, et al. (2012) Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1. Journal of Immunology. 2012;188(5):2127-2135.
  • Alberto Boretti, Bimal Krishna Banik (2020) Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome PharmaNutrition.
    2020 Jun;12:100190. Published online 2020 Apr 21.
  • Sharma M, Anderson A et al.(2009) Induction of multiple pro-inflammatory cytokines by respiratory viruses and reversal by standardized Echinacea, a potent antiviral herbal extract. Antiviral Research, 2009;83(2):165-170.
  • Cannell JJ, Zasloff M, Garland CF et al. (2008) On the epidemiology of influenza.
    Virol J. 2008;5:29.
  • Gorton HC, Jarvis K (1999) The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manip Physiol Ther, 22:8, 530-533
  • Hemilä H (2003) Vitamin C and SARS coronavirus Journal of Antimicrobial Chemotherapy, Volume 52, Issue 6, December 2003, Pages 1049–1050
  • WHO Global advisory committee on vaccine safety 2020 (ikke ændret siden 2006). https://www.who.int/vaccine_safety/committee/topics/adjuvants/squalene/Jun_2006/en/